The average train between Nové Mesto and Prague takes 4h 51m and the fastest train takes 4h 40m. The train service runs several times per day from Nové Mesto to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Nové Mesto and Prague. The earliest departure is at 4:25 AM at night, and the last departure from Nové Mesto is at 7:37 PM which arrives into Prague at 12:25 AM. All services require a transfer at Hlavná stanica and take an average of 4h 51m. The schedules shown below are for the next available departures.

4h 42m • 1 change

4h 47m • 1 change

4h 46m • 1 change

4h 46m • 1 change

5h 30m • 1 change

5h • 1 change

4h 42m • 1 change

4h 43m • 1 change

5h 30m • 1 change

5h • 1 change

4h 42m • 1 change

4h 43m • 1 change

5h 30m • 1 change

5h • 1 change

4h 42m • 1 change

4h 43m • 1 change

5h 30m • 1 change

5h • 1 change

4h 42m • 1 change

4h 43m • 1 change
Want to know about travelling from Nové Mesto to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Nové Mesto to Prague. However, there are services departing from Nové Mesto station and arriving at Prague station via Praha Hlavni Nadrazi. The journey, including transfers, takes approximately 4h 51m.
Nové Mesto to Prague train services, operated by Slovakia Public Transport, depart from Bratislava Hlavna Stanica station.
Nové Mesto to Prague train services, operated by Slovakia Public Transport, arrive at Praha Hlavni Nadrazi station.
Book your Nové Mesto to Prague train tickets online with Slovakia Public Transport, Hungarian Railways (MÁV) and 4 other operators.
The distance between Nové Mesto and Prague is 291 km. The road distance is 397 km.
Railjet operates a train from Bratislava Hlavna Stanica to Praha Hlavni Nadrazi every 4 hours. Tickets cost Kč 1,300–2,100 and the journey takes 4h 25m. Four other operators also service this route.