The train between Nyon and Domodossola takes 2h 35m. The train service runs several times per day from Nyon to Domodossola. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Nyon and Domodossola. The earliest departure is at 5:35 AM in the morning, and the last departure from Nyon is at 6:35 PM which arrives into Domodossola at 9:10 PM. All services require a transfer, and take on average 2h 35m. The schedules shown below are for the next available departures.

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Want to know about travelling from Nyon to Domodossola? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Nyon to Domodossola. However, there are services departing from Nyon station and arriving at Domodossola station via Lausanne. The journey, including transfers, takes approximately 2h 35m.
Nyon to Domodossola train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Nyon station.
Nyon to Domodossola train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Domodossola station.
Book your Nyon to Domodossola train tickets online with Swiss Federal Railways (SBB CFF FFS).
The distance between Nyon and Domodossola is 160.7 km. The road distance is 221 km.
You can take a train from Nyon to Domodossola via Lausanne in around 3h 34m.