The average train between Osnabrück and Mainz takes 3h 59m and the fastest train takes 3h 45m. There is a train service every few hours from Osnabrück to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Osnabrück and Mainz. The earliest departure is at 12:38 AM at night, and the last departure from Osnabrück is at 9:37 PM which arrives into Mainz at 2:52 AM. All services require a transfer, and take on average 3h 59m. The schedules shown below are for the next available departures.

6h 45m • 1 change

3h 46m • 1 change

3h 46m • 1 change

3h 46m • 1 change

6h 45m • 1 change

3h 46m • 1 change

3h 46m • 1 change

3h 46m • 1 change

6h 44m • 1 change

3h 45m • 1 change

3h 45m • 1 change

3h 45m • 1 change
Want to know about travelling from Osnabrück to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Osnabrück to Mainz. However, there are services departing from Osnabrück station and arriving at Mainz station via Frankfurt. The journey, including transfers, takes approximately 3h 59m.
Osnabrück to Mainz train services, operated by Deutsche Bahn Intercity (DB IC), depart from Osnabrück Hbf station.
Osnabrück to Mainz train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Frankfurt station.
Book your Osnabrück to Mainz train tickets online with Deutsche Bahn Intercity (DB IC) and Deutsche Bahn Regio (DB Regional).
The distance between Osnabrück and Mainz is 255 km. The road distance is 395 km.
Deutsche Bahn Intercity (DB IC) operates a train from Osnabrück Hbf to Frankfurt hourly. Tickets cost €65–290 and the journey takes 3h 12m.