The average train between Osnabrück and Mainz takes 3h 57m and the fastest train takes 3h 45m. There is a train service every few hours from Osnabrück to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Osnabrück and Mainz. The earliest departure is at 12:38 AM at night, and the last departure from Osnabrück is at 9:37 PM which arrives into Mainz at 3:52 AM. All services require a transfer, and take on average 3h 57m. The schedules shown below are for the next available departures.

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3h 45m • 1 changeWant to know about travelling from Osnabrück to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Osnabrück to Mainz. However, there are services departing from Osnabrück Hbf station and arriving at Frankfurt station via Frankfurt station. The journey, including transfers, takes approximately 3h 57m.
Osnabrück to Mainz train services, operated by Deutsche Bahn Intercity (DB IC), depart from Osnabrück Hbf station.
Osnabrück to Mainz train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Frankfurt station.
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The distance between Osnabrück and Mainz is 255 km. The road distance is 324 km.
Deutsche Bahn Intercity (DB IC) operates a train from Osnabrück Hbf to Frankfurt hourly. Tickets cost €60–120 and the journey takes 3h 12m.