The average train between Oxford and Holyhead takes 5h 57m and the fastest train takes 5h 8m. The train service runs several times per day from Oxford to Holyhead. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Oxford and Holyhead. The earliest departure is at 6:39 AM in the morning, and the last departure from Oxford is at 9:09 PM which arrives into Holyhead at 8:24 AM. All services require a transfer, and take on average 5h 57m. The schedules shown below are for the next available departures.

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5h 8m • 1 changeArrives next day

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5h 15m • 1 changeWant to know about travelling from Oxford to Holyhead? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Oxford to Holyhead. However, there are services departing from Oxford station and arriving at Holyhead station via Stafford. The journey, including transfers, takes approximately 5h 57m.
Oxford to Holyhead train services, operated by Cross Country, depart from Oxford station.
Oxford to Holyhead train services, operated by Cross Country, arrive at Holyhead station.
Book your Oxford to Holyhead train tickets online with Cross Country and Avanti West Coast.
The distance between Oxford and Holyhead is 286.7 km. The road distance is 367 km.
You can take a train from Oxford to Holyhead via Stafford in around 5h 21m.