The average train between Paderborn and Karlsruhe takes 5h 19m and the fastest train takes 4h 29m. The train service runs several times per day from Paderborn to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Paderborn and Karlsruhe. The earliest departure is at 5:43 AM in the morning, and the last departure from Paderborn is at 10:48 PM which arrives into Karlsruhe at 9:19 AM. All services require a transfer, and take on average 5h 19m. The schedules shown below are for the next available departures.

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5h 31m • 1 changeWant to know about travelling from Paderborn to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Paderborn to Karlsruhe. However, there are services departing from Paderborn Hbf station and arriving at Karlsruhe Hauptbahnhof station via Kassel-Wilhelmshoehe station. The journey, including transfers, takes approximately 5h 19m.
Paderborn to Karlsruhe train services, operated by National Express, depart from Paderborn Hbf station.
Paderborn to Karlsruhe train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Karlsruhe Hauptbahnhof station.
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The distance between Paderborn and Karlsruhe is 302.3 km. The road distance is 349 km.
You can take a train from Paderborn Hbf to Karlsruhe Hauptbahnhof via Kassel Bahnhof Wilhelmshöhe in around 4h 29m.