The average train between Palermo and Sesto Calende takes 25h 8m and the fastest train takes 23h 59m. The train service runs several times per day from Palermo to Sesto Calende. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Palermo and Sesto Calende. The earliest departure is at 7:05 AM in the morning, and the last departure from Palermo is at 10:15 AM which arrives into Sesto Calende at 12:32 PM. All services require a transfer at Roma Termini and take an average of 25h 8m. The schedules shown below are for the next available departures.
Arrives next day


23h 59m • 2 changes
Arrives next day


26h 17m • 2 changes
Arrives next day


23h 59m • 2 changes
Arrives next day


26h 17m • 2 changes
Arrives next day


23h 59m • 2 changes
Arrives next day


26h 17m • 2 changes
Arrives next day


23h 59m • 2 changes
Arrives next day


26h 17m • 2 changes
Want to know about travelling from Palermo to Sesto Calende? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Palermo to Sesto Calende. However, there are services departing from Palermo station and arriving at Sesto Calende station via Roma Termini. The journey, including transfers, takes approximately 25h 8m.
Palermo to Sesto Calende train services, operated by Trenitalia Intercity, depart from Palermo Centrale station.
Palermo to Sesto Calende train services, operated by Trenitalia Intercity, arrive at Sesto Calende station.
Book your Palermo to Sesto Calende train tickets online with Trenitalia Intercity, ItaloTreno and Trenitalia.
The distance between Palermo and Sesto Calende is 929 km. The road distance is 1,483 km.
You can take a train from Palermo Centrale to Sesto Calende via Roma Termini and Rho-Fiera Milano in around 16h 8m.