The average train between Piazza del Duomo and Rome takes 4h 8m and the fastest train takes 3h 22m. There is a train service every few hours from Piazza del Duomo to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Piazza del Duomo and Rome. The earliest departure is at 12:13 AM at night, and the last departure from Piazza del Duomo is at 7:20 PM which arrives into Rome at 11:24 PM. All services require a transfer at Duomo M1 and take an average of 4h 8m. The schedules shown below are for the next available departures.

3h 28m • 1 change

3h 58m • 1 change

3h 28m • 1 change

4h • 1 change

8h 50m • 1 change

3h 28m • 1 change

3h 26m • 1 change

4h 6m • 1 change

9h 10m • 1 change

3h 28m • 1 change

3h 26m • 1 change

4h 6m • 1 change

9h 10m • 1 change

3h 29m • 1 change

3h 29m • 1 change

4h 3m • 1 change
Want to know about travelling from Piazza del Duomo to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Piazza del Duomo to Rome. However, there are services departing from Piazza del Duomo station and arriving at Rome station via Roma Termini. The journey, including transfers, takes approximately 4h 8m.
Piazza del Duomo to Rome train services, operated by ATM, depart from Milano Rogoredo station.
Piazza del Duomo to Rome train services, operated by ATM, arrive at Roma Termini station.
The distance between Piazza del Duomo and Rome is 477.2 km. The road distance is 582 km.
ItaloTreno operates a train from Milano Rogoredo to Roma Termini every 30 minutes. Tickets cost €70–150 and the journey takes 2h 55m.