The average train between Piazza del Duomo and Rome takes 3h 49m and the fastest train takes 3h 30m. There is a train service every few hours from Piazza del Duomo to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Piazza del Duomo and Rome. The earliest departure is at 5:20 AM in the morning, and the last departure from Piazza del Duomo is at 7:10 PM which arrives into Rome at 11:24 PM. All services require a transfer at via grossi and take an average of 3h 49m. The schedules shown below are for the next available departures.

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3h 30m • 1 changeWant to know about travelling from Piazza del Duomo to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Piazza del Duomo to Rome. However, there are services departing from Milano Centrale station and arriving at Roma Termini station via Roma Termini station. The journey, including transfers, takes approximately 3h 49m.
Piazza del Duomo to Rome train services, operated by ItaloTreno, depart from Milano Centrale station.
Piazza del Duomo to Rome train services, operated by ItaloTreno, arrive at Roma Termini station.
The distance between Piazza del Duomo and Rome is 477.2 km. The road distance is 571 km.
ItaloTreno operates a train from Milano Centrale to Roma Termini every 30 minutes. Tickets cost €65–110 and the journey takes 3h 5m.