The average train between Piazza del Duomo and Santo Spirito takes 2h 27m and the fastest train takes 2h 3m. There is a train service every few hours from Piazza del Duomo to Santo Spirito. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Piazza del Duomo and Santo Spirito. The earliest departure is at 12:37 AM at night, and the last departure from Piazza del Duomo is at 9:03 PM which arrives into Santo Spirito at 11:14 PM. All services require a transfer at Duomo M3 and take an average of 2h 27m. The schedules shown below are for the next available departures.

2h 15m • 1 change

2h 5m • 1 change

2h 12m • 1 change

2h 14m • 1 change

6h 27m • 1 change

2h 14m • 1 change

2h 18m • 1 change

2h 12m • 1 change

6h 27m • 1 change

2h 14m • 1 change

2h 18m • 1 change

2h 12m • 1 change

6h 27m • 1 change

2h 14m • 1 change

2h 18m • 1 change

2h 12m • 1 change
Want to know about travelling from Piazza del Duomo to Santo Spirito? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Piazza del Duomo to Santo Spirito. However, there are services departing from Piazza del Duomo station and arriving at Santo Spirito station via Firenze S.M.N.. The journey, including transfers, takes approximately 2h 27m.
Piazza del Duomo to Santo Spirito train services, operated by ATM, depart from Milano Rogoredo station.
Piazza del Duomo to Santo Spirito train services, operated by ATM, arrive at Firenze S.M.N. station.
The distance between Piazza del Duomo and Santo Spirito is 249.3 km. The road distance is 303 km.
Trenitalia Frecce operates a train from Milano Rogoredo to Firenze S.M.N. every 30 minutes. Tickets cost €40–90 and the journey takes 1h 45m. Two other operators also service this route.