The average train between Pilsen and Brno takes 4h 21m and the fastest train takes 4h 13m. There is an hourly train service from Pilsen to Brno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Pilsen and Brno. The earliest departure is at 4:22 AM at night, and the last departure from Pilsen is at 10:00 PM which arrives into Brno at 2:49 AM. All services require a transfer, and take on average 4h 21m. The schedules shown below are for the next available departures.

4h 13m • 1 change

4h 18m • 1 change

4h 13m • 1 change

4h 20m • 1 change

4h 18m • 1 change

4h 16m • 1 change

4h 18m • 1 change

4h 13m • 1 change

4h 18m • 1 change

4h 16m • 1 change

4h 18m • 1 change

4h 13m • 1 change
Want to know about travelling from Pilsen to Brno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pilsen to Brno. However, there are services departing from Pilsen station and arriving at Brno station via Praha Hlavni Nadrazi. The journey, including transfers, takes approximately 4h 21m.
Pilsen to Brno train services, operated by Die Länderbahn, depart from Plzen Hlavni Nadrazi station.
Pilsen to Brno train services, operated by Die Länderbahn, arrive at Brno Hlavni Nadrazi station.
Book your Pilsen to Brno train tickets online with Die Länderbahn, České dráhy (ČD) and 2 other operators.
The distance between Pilsen and Brno is 241.3 km. The road distance is 352 km.
You can take a train from Plzen Hlavni Nadrazi to Brno Hlavni Nadrazi via Praha Hlavni Nadrazi in around 4h 14m.