The average train between Pisa Centrale and Milan takes 3h 54m and the fastest train takes 3h 46m. There is a train service every few hours from Pisa Centrale to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Pisa Centrale and Milan. The earliest departure is at 4:15 AM at night, and the last departure from Pisa Centrale is at 8:32 PM which arrives into Milan at 12:20 AM. All services require a transfer, and take on average 3h 54m. The schedules shown below are for the next available departures.

3h 53m • 1 change

3h 53m • 1 change

3h 48m • 1 change

3h 58m • 1 change

4h 6m • 1 change

3h 51m • 1 change

3h 46m • 1 change

3h 48m • 1 change

4h 6m • 1 change

3h 51m • 1 change

3h 46m • 1 change

3h 48m • 1 change

4h 6m • 1 change

3h 51m • 1 change

3h 46m • 1 change

3h 48m • 1 change
Want to know about travelling from Pisa Centrale to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pisa Centrale to Milan. However, there are services departing from Pisa Centrale station and arriving at Milan station via Firenze S.M.N.. The journey, including transfers, takes approximately 3h 54m.
Pisa Centrale to Milan train services, operated by Trenitalia, depart from Pisa Centrale station.
Pisa Centrale to Milan train services, operated by Trenitalia, arrive at Milano Centrale station.
Book your Pisa Centrale to Milan train tickets online with Trenitalia and Trenitalia Frecce.
The distance between Pisa Centrale and Milan is 217.5 km. The road distance is 382 km.
You can take a train from Pisa Centrale to Milano Centrale via Firenze S.M.N. in around 3h 36m.