The average train between Pisa and Acqui Terme takes 4h 35m and the fastest train takes 3h 43m. The train service runs several times per day from Pisa to Acqui Terme. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Pisa and Acqui Terme. The earliest departure is at 6:42 AM in the morning, and the last departure from Pisa is at 10:43 PM which arrives into Acqui Terme at 8:35 AM. All services require a transfer, and take on average 4h 35m. The schedules shown below are for the next available departures.

3h 57m • 1 change

3h 52m • 1 change

3h 51m • 1 change

4h • 1 change

3h 57m • 1 change

3h 52m • 1 change

3h 51m • 1 change

4h • 1 change

3h 57m • 1 change

3h 52m • 1 change

3h 51m • 1 change

4h • 1 change

3h 57m • 1 change

3h 52m • 1 change

3h 51m • 1 change

4h • 1 change

3h 57m • 1 change

3h 52m • 1 change

3h 51m • 1 change

4h • 1 change

3h 57m • 1 change

4h 53m • 1 change

4h • 1 change

5h 13m • 1 change
Want to know about travelling from Pisa to Acqui Terme? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pisa to Acqui Terme. However, there are services departing from Pisa station and arriving at Acqui Terme station via Genova P.Za Principe. The journey, including transfers, takes approximately 4h 35m.
Pisa to Acqui Terme train services, operated by Trenitalia Intercity, depart from Pisa Centrale station.
Pisa to Acqui Terme train services, operated by Trenitalia Intercity, arrive at Acqui Terme station.
Book your Pisa to Acqui Terme train tickets online with Trenitalia Intercity, Trenitalia and Trenitalia Frecce.
The distance between Pisa and Acqui Terme is 188 km. The road distance is 219 km.
You can take a train from Pisa Centrale to Acqui Terme via Genova P.Za Principe in around 3h 48m.