The average train between Pisa and Guidonia takes 6h 20m and the fastest train takes 3h 37m. The train service runs several times per day from Pisa to Guidonia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Pisa and Guidonia. The earliest departure is at 7:33 AM in the morning, and the last departure from Pisa is at 8:38 PM which arrives into Guidonia at 7:48 AM. All services require a transfer, and take on average 6h 20m. The schedules shown below are for the next available departures.

3h 37m • 1 change

3h 57m • 1 change
Arrives next day

10h 50m • 1 change

3h 37m • 1 change

3h 57m • 1 change
Arrives next day

10h 50m • 1 change

3h 37m • 1 change

3h 57m • 1 change
Arrives next day

10h 50m • 1 change

3h 37m • 1 change

3h 57m • 1 change
Arrives next day

10h 50m • 1 change
Want to know about travelling from Pisa to Guidonia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pisa to Guidonia. However, there are services departing from Pisa station and arriving at Guidonia station via Roma Tiburtina. The journey, including transfers, takes approximately 6h 20m.
Pisa to Guidonia train services, operated by Trenitalia Frecce, depart from Pisa Centrale station.
Pisa to Guidonia train services, operated by Trenitalia Frecce, arrive at Guidonia Montecelio station.
Book your Pisa to Guidonia train tickets online with Trenitalia Frecce and Trenitalia.
The distance between Pisa and Guidonia is 268.4 km. The road distance is 354 km.
You can take a train from Pisa Centrale to Guidonia Montecelio via Roma Tiburtina in around 3h 5m.