The average train between Pisa and Karlsruhe takes 11h 48m and the fastest train takes 9h 45m. The train service runs several times per day from Pisa to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Pisa and Karlsruhe. The earliest departure is at 6:29 AM in the morning, and the last departure from Pisa is at 8:32 PM which arrives into Karlsruhe at 1:57 PM. All services require a transfer at Firenze S.M.N. and take an average of 11h 48m. The schedules shown below are for the next available departures.



10h 28m • 3 changes


9h 45m • 3 changes


10h 26m • 3 changesArrives next day



10h 48m • 3 changes


10h 28m • 3 changes


9h 45m • 3 changes


10h 26m • 3 changesArrives next day



10h 48m • 3 changes


10h 28m • 3 changes


9h 45m • 3 changes


10h 26m • 3 changesArrives next day



16h 1m • 3 changesWant to know about travelling from Pisa to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pisa to Karlsruhe. However, there are services departing from Pisa Centrale station and arriving at Karlsruhe Hauptbahnhof station via Firenze S.M.N. station, Milano Centrale station and Basel Sbb station. The journey, including transfers, takes approximately 11h 48m.
Pisa to Karlsruhe train services, operated by Trenitalia, depart from Pisa Centrale station.
Pisa to Karlsruhe train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Karlsruhe Hauptbahnhof station.
Book your Pisa to Karlsruhe train tickets online with Omio.
The distance between Pisa and Karlsruhe is 609 km. The road distance is 808 km.
You can take a train from Pisa Centrale to Karlsruhe Hauptbahnhof via Firenze S.M.N., Milano Centrale, and Basel SBB in around 11h 4m.