The average train between Pisa and Mestre takes 3h 24m and the fastest train takes 3h 10m. There is a train service every few hours from Pisa to Mestre. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Pisa and Mestre. The earliest departure is at 5:53 AM in the morning, and the last departure from Pisa is at 8:06 PM which arrives into Mestre at 11:23 PM. All services require a transfer, and take on average 3h 24m. The schedules shown below are for the next available departures.

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Want to know about travelling from Pisa to Mestre? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pisa to Mestre. However, there are services departing from Pisa station and arriving at Mestre station via Firenze S.M.N.. The journey, including transfers, takes approximately 3h 24m.
Pisa to Mestre train services, operated by Trenitalia, depart from Pisa Centrale station.
Pisa to Mestre train services, operated by Trenitalia, arrive at Venezia Mestre station.
Book your Pisa to Mestre train tickets online with Trenitalia and Trenitalia Frecce.
The distance between Pisa and Mestre is 246.1 km. The road distance is 320 km.
You can take a train from Pisa Centrale to Venezia Mestre via Firenze S.M.N. in around 3h 51m.