The average train between Pisa and Sezze takes 4h 56m and the fastest train takes 3h 22m. The train service runs several times per day from Pisa to Sezze. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Pisa and Sezze. The earliest departure is at 7:07 AM in the morning, and the last departure from Pisa is at 8:38 PM which arrives into Sezze at 12:01 AM. All services require a transfer, and take on average 4h 56m. The schedules shown below are for the next available departures.

4h 30m • 1 change

4h 32m • 1 change

4h 18m • 1 change

5h 19m • 1 change

3h 51m • 1 change

4h 22m • 1 change

5h 16m • 1 change

4h 57m • 1 change

3h 51m • 1 change

4h 22m • 1 change

5h 14m • 1 change

4h 57m • 1 change

3h 51m • 1 change

3h 22m • 1 change

4h 20m • 1 change

4h 24m • 1 change

4h 51m • 1 change

4h 10m • 1 change

4h 17m • 1 change

4h 12m • 1 change

4h 17m • 1 change

4h 30m • 1 change

5h 16m • 1 change

4h 57m • 1 change

3h 51m • 1 change

4h 22m • 1 change

5h 16m • 1 change

4h 57m • 1 change
Want to know about travelling from Pisa to Sezze? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pisa to Sezze. However, there are services departing from Pisa station and arriving at Sezze station via Roma Termini. The journey, including transfers, takes approximately 4h 56m.
Pisa to Sezze train services, operated by Trenitalia Frecce, depart from Pisa Centrale station.
Pisa to Sezze train services, operated by Trenitalia Frecce, arrive at Sezze Romano station.
Book your Pisa to Sezze train tickets online with Trenitalia Frecce, Trenitalia and Trenitalia Intercity.
The distance between Pisa and Sezze is 328 km. The road distance is 401 km.
You can take a train from Pisa Centrale to Sezze Romano via Roma Termini in around 4h 12m.