The average train between Pisa and Spoleto takes 7h 35m and the fastest train takes 5h 30m. The train service runs several times per day from Pisa to Spoleto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Pisa and Spoleto. The earliest departure is at 7:33 AM in the morning, and the last departure from Pisa is at 8:38 PM which arrives into Spoleto at 7:16 AM. All services require a transfer, and take on average 7h 35m. The schedules shown below are for the next available departures.

6h 18m • 1 change

5h 40m • 1 change
Arrives next day

10h 38m • 1 change

6h 18m • 1 change

5h 40m • 1 change
Arrives next day

10h 38m • 1 change

6h 18m • 1 change

5h 40m • 1 change
Arrives next day

10h 38m • 1 change

6h 18m • 1 change

5h 40m • 1 change
Arrives next day

10h 38m • 1 change
Want to know about travelling from Pisa to Spoleto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pisa to Spoleto. However, there are services departing from Pisa station and arriving at Spoleto station via Roma Tiburtina. The journey, including transfers, takes approximately 7h 35m.
Pisa to Spoleto train services, operated by Trenitalia Frecce, depart from Pisa Centrale station.
Pisa to Spoleto train services, operated by Trenitalia Frecce, arrive at Spoleto station.
Book your Pisa to Spoleto train tickets online with Trenitalia Frecce and Trenitalia.
The distance between Pisa and Spoleto is 217.7 km. The road distance is 451 km.
You can take a train from Pisa Centrale to Spoleto via Roma Tiburtina in around 3h 52m.