The average train between Plymouth and Middlesex takes 3h 52m and the fastest train takes 3h 24m. There is a train service every few hours from Plymouth to Middlesex. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Plymouth and Middlesex. The earliest departure is at 4:54 AM at night, and the last departure from Plymouth is at 11:56 PM which arrives into Middlesex at 6:12 AM. All services require a transfer at London Paddington and take an average of 3h 52m. The schedules shown below are for the next available departures.

3h 33m • 1 change

3h 51m • 1 change

3h 41m • 1 change

3h 41m • 1 change

4h 10m • 1 change

3h 54m • 1 change

4h 1m • 1 change

3h 33m • 1 change

4h • 1 change

3h 55m • 1 change

3h 35m • 1 change

3h 34m • 1 change
Want to know about travelling from Plymouth to Middlesex? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Plymouth to Middlesex. However, there are services departing from Plymouth station and arriving at Middlesex station via London Paddington. The journey, including transfers, takes approximately 3h 52m.
Plymouth to Middlesex train services, operated by Great Western Railway (GWR), depart from Plymouth station.
Plymouth to Middlesex train services, operated by Great Western Railway (GWR), arrive at London Paddington station.
Book your Plymouth to Middlesex train tickets online with Great Western Railway (GWR) and London Underground (Tube).
The distance between Plymouth and Middlesex is 300.5 km. The road distance is 368 km.
Great Western Railway (GWR) operates a train from Plymouth to London Paddington hourly. Tickets cost £100–190 and the journey takes 3h 14m.