The average train between Plymouth and Milton Keynes takes 5h 1m and the fastest train takes 4h 31m. There is a train service every few hours from Plymouth to Milton Keynes. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Plymouth and Milton Keynes. The earliest departure is at 5:25 AM in the morning, and the last departure from Plymouth is at 8:08 PM which arrives into Milton Keynes at 6:42 AM. All services require a transfer, and take on average 5h 1m. The schedules shown below are for the next available departures.

4h 50m • 1 change

4h 55m • 1 change

4h 48m • 1 change

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4h 50m • 1 change

4h 55m • 1 change

4h 48m • 1 change

4h 48m • 1 change

4h 48m • 1 change

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4h 48m • 1 change

4h 48m • 1 change

5h 3m • 1 change
Want to know about travelling from Plymouth to Milton Keynes? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Plymouth to Milton Keynes. However, there are services departing from Plymouth station and arriving at Milton Keynes station via Birmingham New Street. The journey, including transfers, takes approximately 5h 1m.
Plymouth to Milton Keynes train services, operated by Cross Country, depart from Plymouth station.
Plymouth to Milton Keynes train services, operated by Cross Country, arrive at Milton Keynes Central station.
Book your Plymouth to Milton Keynes train tickets online with Cross Country, Avanti West Coast and West Midlands Trains.
The distance between Plymouth and Milton Keynes is 300.2 km. The road distance is 449 km.
You can take a train from Plymouth to Milton Keynes Central via Birmingham New Street in around 4h 36m.