The average train between Plymouth and Slough takes 3h 29m and the fastest train takes 3h 6m. There is a train service every few hours from Plymouth to Slough. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Plymouth and Slough. The earliest departure is at 4:54 AM at night, and the last departure from Plymouth is at 11:56 PM which arrives into Slough at 4:34 AM. All services require a transfer, and take on average 3h 29m. The schedules shown below are for the next available departures.

3h 16m • 1 change

3h 16m • 1 change

3h 15m • 1 change

3h 15m • 1 change

3h 42m • 1 change

3h 35m • 1 change

3h 36m • 1 change

3h 16m • 1 change

3h 35m • 1 change

3h 37m • 1 change

3h 17m • 1 change

3h 17m • 1 change

3h 54m • 1 change

3h 21m • 1 change

3h 32m • 1 change

3h 32m • 1 change
Want to know about travelling from Plymouth to Slough? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Plymouth to Slough. However, there are services departing from Plymouth station and arriving at Slough station via Reading. The journey, including transfers, takes approximately 3h 29m.
Plymouth to Slough train services, operated by Great Western Railway (GWR), depart from Plymouth station.
Plymouth to Slough train services, operated by Great Western Railway (GWR), arrive at Reading station.
Book your Plymouth to Slough train tickets online with Great Western Railway (GWR) and Elizabeth Line (TfL).
The distance between Plymouth and Slough is 278.9 km. The road distance is 331 km.
Great Western Railway (GWR) operates a train from Plymouth to Reading hourly. Tickets cost £85–160 and the journey takes 2h 48m.