The average train between Pont-Saint-Esprit and Lyon takes 3h 14m and the fastest train takes 2h 12m. There is at least one train per day from Pont-Saint-Esprit to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run once daily between Pont-Saint-Esprit and Lyon. The earliest departure is at 7:01 AM in the morning, and the last departure from Pont-Saint-Esprit is at 7:55 PM which arrives into Lyon at 10:07 PM. All services require a transfer at Avignon Centre and take an average of 3h 14m. The schedules shown below are for the next available departures.


2h 53m • 2 changes


3h 51m • 2 changes


3h 24m • 2 changes


2h 45m • 2 changes
Want to know about travelling from Pont-Saint-Esprit to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pont-Saint-Esprit to Lyon. However, there are services departing from Pont-Saint-Esprit station and arriving at Lyon station via Avignon Centre. The journey, including transfers, takes approximately 3h 14m.
Pont-Saint-Esprit to Lyon train services, operated by Zou! Lignes Express Régionales, depart from Pont-Saint-Esprit station.
Pont-Saint-Esprit to Lyon train services, operated by Zou! Lignes Express Régionales, arrive at Lyon Part Dieu station.
Book your Pont-Saint-Esprit to Lyon train tickets online with Zou! Lignes Express Régionales and TGV inOui.
The distance between Pont-Saint-Esprit and Lyon is 166.9 km. The road distance is 278 km.
You can take a train from Pont-Saint-Esprit to Lyon Part Dieu via Avignon Centre and Avignon Tgv in around 2h 18m.