The average train between Prague Castle and Brno takes 3h 2m and the fastest train takes 2h 46m. There is an hourly train service from Prague Castle to Brno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Prague Castle and Brno. The earliest departure is at 5:19 AM in the morning, and the last departure from Prague Castle is at 11:59 PM which arrives into Brno at 7:13 AM. All services require a transfer at Dejvická and take an average of 3h 2m. The schedules shown below are for the next available departures.

2h 46m • 1 change

2h 47m • 1 change

3h 6m • 1 change
Arrives next day

2h 56m • 1 change

2h 53m • 1 change

2h 50m • 1 change

2h 48m • 1 change

2h 50m • 1 change

2h 53m • 1 change

2h 50m • 1 change

2h 48m • 1 change

2h 50m • 1 change
Want to know about travelling from Prague Castle to Brno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague Castle to Brno. However, there are services departing from Prague Castle station and arriving at Brno station via Brno Hlavni Nadrazi. The journey, including transfers, takes approximately 3h 2m.
Prague Castle to Brno train services, operated by Pražská integrovaná doprava, depart from Praha Hlavni Nadrazi station.
Prague Castle to Brno train services, operated by Pražská integrovaná doprava, arrive at Brno Hlavni Nadrazi station.
The distance between Prague Castle and Brno is 188.3 km. The road distance is 258 km.
České dráhy (ČD) operates a train from Praha Hlavni Nadrazi to Brno Hlavni Nadrazi every 30 minutes. Tickets cost Kč 700–1,100 and the journey takes 2h 36m. Two other operators also service this route.