The average train between Prague and Hustopeče takes 4h 4m and the fastest train takes 3h 40m. There is a train service every few hours from Prague to Hustopeče. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Prague and Hustopeče. The earliest departure is at 4:35 AM at night, and the last departure from Prague is at 8:58 PM which arrives into Hustopeče at 4:55 AM. All services require a transfer, and take on average 4h 4m. The schedules shown below are for the next available departures.

4h 20m • 1 change

3h 54m • 1 change

3h 54m • 1 change

3h 57m • 1 change

3h 54m • 1 change

3h 54m • 1 change

3h 57m • 1 change

3h 54m • 1 change

3h 43m • 1 change

3h 54m • 1 change

3h 54m • 1 change

3h 57m • 1 change
Want to know about travelling from Prague to Hustopeče? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Hustopeče. However, there are services departing from Prague station and arriving at Hustopeče station via Brno Hlavni Nadrazi. The journey, including transfers, takes approximately 4h 4m.
Prague to Hustopeče train services, operated by České dráhy (ČD), depart from Praha Hlavni Nadrazi station.
Prague to Hustopeče train services, operated by České dráhy (ČD), arrive at Hustopece U Brna station.
Book your Prague to Hustopeče train tickets online with České dráhy (ČD), RegioJet and ÖBB EuroCity.
The distance between Prague and Hustopeče is 210.4 km. The road distance is 293 km.
You can take a train from Praha Hlavni Nadrazi to Hustopece U Brna via Brno Hlavni Nadrazi in around 3h 35m.