The average train between Prague and Köthen takes 5h 20m and the fastest train takes 4h 54m. The train service runs several times per day from Prague to Köthen. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Prague and Köthen. The earliest departure is at 12:33 AM at night, and the last departure from Prague is at 4:31 PM which arrives into Köthen at 9:25 PM. All services require a transfer, and take on average 5h 20m. The schedules shown below are for the next available departures.

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8h 52m • 1 change

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Want to know about travelling from Prague to Köthen? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Köthen. However, there are services departing from Prague station and arriving at Köthen station via Dresden Hbf. The journey, including transfers, takes approximately 5h 20m.
Prague to Köthen train services, operated by České dráhy (ČD), depart from Praha Hlavni Nadrazi station.
Prague to Köthen train services, operated by České dráhy (ČD), arrive at Köthen station.
Book your Prague to Köthen train tickets online with České dráhy (ČD) and Deutsche Bahn Intercity (DB IC).
The distance between Prague and Köthen is 252.4 km. The road distance is 379 km.
You can take a train from Praha Hlavni Nadrazi to Köthen via Dresden Hauptbahnhof in around 5h 22m.