Prague to Mainz, Hauptbahnhof Trains

Prague to Mainz, Hauptbahnhof trains

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Trip Overview

The average train between Prague and Mainz, Hauptbahnhof takes 9h 58m and the fastest train takes 8h 39m. The train service runs several times per day from Prague to Mainz, Hauptbahnhof. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

9h 58m
Duration: 650 km
Distance: €144
Average price: Every 4 hours
Frequency

Train via Regensburg

best

Take the train from Praha Hlavni Nadrazi to Regensburg Hbftrain Ec
Take the train from Regensburg Hbf to Mainz Hbftrain Ice / ...

8h 49m

€129–204

Prague to Mainz, Hauptbahnhof train times

Trains run every 4 hours between Prague and Mainz, Hauptbahnhof. The earliest departure is at 5:35 AM in the morning, and the last departure from Prague is at 5:35 PM which arrives into Mainz, Hauptbahnhof at 12:20 PM. All services require a transfer, and take on average 9h 58m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

5:35 PM → 12:20 PM
Arrives next day
18h 45m • 1 change

Departing Friday, November 6, 2026

5:35 AM → 2:18 PM
8h 43m • 1 change
7:35 AM → 4:18 PM
8h 43m • 1 change
9:35 AM → 6:18 PM
8h 43m • 1 change
11:35 AM → 8:18 PM
8h 43m • 1 change
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Departing Saturday, November 7, 2026

5:35 AM → 2:18 PM
8h 43m • 1 change
7:35 AM → 4:18 PM
8h 43m • 1 change
9:35 AM → 6:18 PM
8h 43m • 1 change
11:35 AM → 8:26 PM
8h 51m • 1 change
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Departing Sunday, November 8, 2026

5:35 AM → 2:18 PM
8h 43m • 1 change
7:35 AM → 4:18 PM
8h 43m • 1 change
9:35 AM → 6:18 PM
8h 43m • 1 change
11:35 AM → 8:18 PM
8h 43m • 1 change
Show more

Departing Monday, November 9, 2026

5:35 AM → 2:18 PM
8h 43m • 1 change
7:35 AM → 4:18 PM
8h 43m • 1 change
9:35 AM → 6:18 PM
8h 43m • 1 change
11:35 AM → 8:21 PM
8h 46m • 1 change
Show more

Departing Tuesday, November 10, 2026

5:35 AM → 2:18 PM
8h 43m • 1 change
7:35 AM → 4:18 PM
8h 43m • 1 change
9:35 AM → 6:18 PM
8h 43m • 1 change
11:35 AM → 8:18 PM
8h 43m • 1 change
Show more

Departing Wednesday, November 11, 2026

5:35 AM → 2:18 PM
8h 43m • 1 change
7:35 AM → 4:18 PM
8h 43m • 1 change
9:35 AM → 6:18 PM
8h 43m • 1 change
11:35 AM → 8:18 PM
8h 43m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Prague to Mainz, Hauptbahnhof? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.