The average train between Prague and Mainz-Kastel takes 10h 15m and the fastest train takes 8h 14m. The train service runs several times per day from Prague to Mainz-Kastel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Prague and Mainz-Kastel. The earliest departure is at 5:35 AM in the morning, and the last departure from Prague is at 5:35 PM which arrives into Mainz-Kastel at 8:49 AM. All services require a transfer at Schwandorf and take an average of 10h 15m. The schedules shown below are for the next available departures.



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10h 44m • 3 changes
Want to know about travelling from Prague to Mainz-Kastel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Mainz-Kastel. However, there are services departing from Prague station and arriving at Mainz-Kastel station via Schwandorf. The journey, including transfers, takes approximately 10h 15m.
Prague to Mainz-Kastel train services, operated by ÖBB EuroCity, depart from Praha Hlavni Nadrazi station.
Prague to Mainz-Kastel train services, operated by ÖBB EuroCity, arrive at Frankfurt station.
Book your Prague to Mainz-Kastel train tickets online with ÖBB EuroCity, Deutsche Bahn Regio (DB Regional) and 2 other operators.
The distance between Prague and Mainz-Kastel is 438.1 km. The road distance is 598 km.
You can take a train from Praha Hlavni Nadrazi to Mainz-Kastel via Schwandorf, Nürnberg Hbf, Frankfurt, and Frankfurt(Main)Hbf in around 8h 58m.