The average train between Prague and Nové Mesto takes 5h 5m and the fastest train takes 4h 33m. The train service runs several times per day from Prague to Nové Mesto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Prague and Nové Mesto. The earliest departure is at 5:42 AM in the morning, and the last departure from Prague is at 7:42 PM which arrives into Nové Mesto at 4:35 AM. All services require a transfer at Bratislava hlavná stanica and take an average of 5h 5m. The schedules shown below are for the next available departures.

4h 34m • 1 change

4h 33m • 1 change

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4h 33m • 1 change

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4h 34m • 1 change

4h 34m • 1 change

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4h 34m • 1 change

4h 34m • 1 change

4h 34m • 1 change

4h 34m • 1 change

4h 34m • 1 change

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4h 34m • 1 change

4h 34m • 1 change

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4h 34m • 1 change
Want to know about travelling from Prague to Nové Mesto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Nové Mesto. However, there are services departing from Prague station and arriving at Nové Mesto station via Bratislava hlavná stanica. The journey, including transfers, takes approximately 5h 5m.
Prague to Nové Mesto train services, operated by ÖBB EuroCity, depart from Praha Hlavní nádraží station.
Prague to Nové Mesto train services, operated by ÖBB EuroCity, arrive at Bratislava hlavná stanica station.
Book your Prague to Nové Mesto train tickets online with ÖBB EuroCity and Slovakia Public Transport.
The distance between Prague and Nové Mesto is 291 km. The road distance is 413 km.
ÖBB EuroCity operates a train from Praha Hlavní nádraží to Bratislava hlavná stanica every 4 hours. Tickets cost €85–160 and the journey takes 4h 20m.