The average train between Prague and Nové Mesto takes 4h 45m and the fastest train takes 4h 38m. The train service runs several times per day from Prague to Nové Mesto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Prague and Nové Mesto. The earliest departure is at 5:37 AM in the morning, and the last departure from Prague is at 5:37 PM which arrives into Nové Mesto at 10:15 PM. All services require a transfer at Bratislava hl.st. and take an average of 4h 45m. The schedules shown below are for the next available departures.

4h 39m • 1 change
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4h 44m • 1 change
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4h 42m • 1 changeWant to know about travelling from Prague to Nové Mesto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Nové Mesto. However, there are services departing from Praha hl.n. station and arriving at Bratislava hl.st. station via Bratislava hl.st. station. The journey, including transfers, takes approximately 4h 45m.
Prague to Nové Mesto train services, operated by Railways of Slovak Republic (ZSSK), depart from Praha hl.n. station.
Prague to Nové Mesto train services, operated by Railways of Slovak Republic (ZSSK), arrive at Bratislava hl.st. station.
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The distance between Prague and Nové Mesto is 291 km. The road distance is 333 km.
Railways of Slovak Republic (ZSSK) operates a train from Praha hl.n. to Bratislava hl.st. every 4 hours. Tickets cost €19–35 and the journey takes 4h 25m. Two other operators also service this route.