The average train between Prague and Wiesbaden takes 9h 59m and the fastest train takes 8h 51m. The train service runs several times per day from Prague to Wiesbaden. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Prague and Wiesbaden. The earliest departure is at 6:41 AM in the morning, and the last departure from Prague is at 8:57 PM which arrives into Wiesbaden at 11:32 AM. All services require a transfer, and take on average 9h 59m. The schedules shown below are for the next available departures.

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8h 51m • 1 changeArrives next day

14h 35m • 1 change
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8h 51m • 1 changeWant to know about travelling from Prague to Wiesbaden? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Wiesbaden. However, there are services departing from Prague station and arriving at Wiesbaden station via Dresden Hbf. The journey, including transfers, takes approximately 9h 59m.
Prague to Wiesbaden train services, operated by České dráhy (ČD), depart from Praha-Holesovice station.
Prague to Wiesbaden train services, operated by České dráhy (ČD), arrive at Wiesbaden Hauptbahnhof station.
Book your Prague to Wiesbaden train tickets online with České dráhy (ČD) and Deutsche Bahn Intercity (DB IC).
The distance between Prague and Wiesbaden is 440.2 km. The road distance is 716 km.
You can take a train from Praha-Holesovice to Wiesbaden Hauptbahnhof via Dresden Hauptbahnhof in around 8h 28m.