The average train between Prague and Wuppertal takes 9h 31m and the fastest train takes 8h 3m. The train service runs several times per day from Prague to Wuppertal. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Prague and Wuppertal. The earliest departure is at 6:41 AM in the morning, and the last departure from Prague is at 4:41 PM which arrives into Wuppertal at 8:44 AM. All services require a transfer, and take on average 9h 31m. The schedules shown below are for the next available departures.

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Want to know about travelling from Prague to Wuppertal? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Wuppertal. However, there are services departing from Prague station and arriving at Wuppertal station via Berlin-Spandau. The journey, including transfers, takes approximately 9h 31m.
Prague to Wuppertal train services, operated by České dráhy (ČD), depart from Praha-Holesovice station.
Prague to Wuppertal train services, operated by České dráhy (ČD), arrive at Wuppertal Hbf station.
Book your Prague to Wuppertal train tickets online with České dráhy (ČD), Deutsche Bahn Intercity (DB IC) and Railjet.
The distance between Prague and Wuppertal is 528.5 km. The road distance is 871 km.
You can take a train from Praha-Holesovice to Wuppertal Hbf via S Spandau Bhf in around 8h 23m.