The average train between Rüsselsheim am Main and Brussels takes 3h 8m and the fastest train takes 3h 3m. The train service runs several times per day from Rüsselsheim am Main to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Rüsselsheim am Main and Brussels. The earliest departure is at 6:23 AM in the morning, and the last departure from Rüsselsheim am Main is at 7:46 PM which arrives into Brussels at 11:26 PM. All services require a transfer, and take on average 3h 8m. The schedules shown below are for the next available departures.

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Want to know about travelling from Rüsselsheim am Main to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rüsselsheim am Main to Brussels. However, there are services departing from Rüsselsheim am Main station and arriving at Brussels station via Brussels-Nord. The journey, including transfers, takes approximately 3h 8m.
Rüsselsheim am Main to Brussels train services, operated by vlexx, depart from Frankfurt station.
Rüsselsheim am Main to Brussels train services, operated by vlexx, arrive at Brussels-Nord station.
Book your Rüsselsheim am Main to Brussels train tickets online with vlexx, Deutsche Bahn Intercity (DB IC) and 2 other operators.
The distance between Rüsselsheim am Main and Brussels is 304 km. The road distance is 400 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Brussels-Nord every 4 hours. Tickets cost €70–310 and the journey takes 2h 55m. Belgian Railways (NMBS/SNCB) also services this route 4 times a week.