The average train between Roma Ostiense and Milan takes 3h 42m and the fastest train takes 3h 16m. There is a train service every few hours from Roma Ostiense to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Roma Ostiense and Milan. The earliest departure is at 1:46 AM at night, and the last departure from Roma Ostiense is at 11:45 PM which arrives into Milan at 9:20 AM. All services require a transfer at Piramide and take an average of 3h 42m. The schedules shown below are for the next available departures.

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3h 23m • 1 changeWant to know about travelling from Roma Ostiense to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Roma Ostiense to Milan. However, there are services departing from Roma Termini station and arriving at Milano Centrale station via Milano Centrale station. The journey, including transfers, takes approximately 3h 42m.
Roma Ostiense to Milan train services, operated by ItaloTreno, depart from Roma Termini station.
Roma Ostiense to Milan train services, operated by ItaloTreno, arrive at Milano Centrale station.
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The distance between Roma Ostiense and Milan is 479.2 km. The road distance is 575 km.
ItaloTreno operates a train from Roma Termini to Milano Centrale every 30 minutes. Tickets cost €65–110 and the journey takes 3h 5m.