The average train between Roma Termini and Porta Sempione takes 4h 2m and the fastest train takes 3h 41m. The train service runs several times per day from Roma Termini to Porta Sempione. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Roma Termini and Porta Sempione. The earliest departure is at 6:30 AM in the morning, and the last departure from Roma Termini is at 8:05 PM which arrives into Porta Sempione at 11:51 PM. All services require a transfer at Milano Centrale and take an average of 4h 2m. The schedules shown below are for the next available departures.

3h 41m • 1 change

3h 43m • 1 change

3h 47m • 1 change

3h 46m • 1 change

4h 4m • 1 change

3h 52m • 1 change

4h 25m • 1 change

3h 59m • 1 change

3h 49m • 1 change

3h 46m • 1 change

4h 27m • 1 change

3h 44m • 1 change

3h 49m • 1 change

3h 46m • 1 change

4h 27m • 1 change

3h 44m • 1 change
Want to know about travelling from Roma Termini to Porta Sempione? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Roma Termini to Porta Sempione. However, there are services departing from Roma Termini station and arriving at Porta Sempione station via Milano Centrale. The journey, including transfers, takes approximately 4h 2m.
Roma Termini to Porta Sempione train services, operated by ItaloTreno, depart from Roma Termini station.
Roma Termini to Porta Sempione train services, operated by ItaloTreno, arrive at Milano Centrale station.
Book your Roma Termini to Porta Sempione train tickets online with ItaloTreno and ATM.
The distance between Roma Termini and Porta Sempione is 479.3 km. The road distance is 585 km.
ItaloTreno operates a train from Roma Termini to Milano Centrale every 30 minutes. Tickets cost €70–150 and the journey takes 3h 5m.