The average train between Rome and Desio takes 5h 13m and the fastest train takes 4h 6m. The train service runs several times per day from Rome to Desio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Rome and Desio. The earliest departure is at 4:55 AM at night, and the last departure from Rome is at 7:50 PM which arrives into Desio at 7:21 AM. All services require a transfer, and take on average 5h 13m. The schedules shown below are for the next available departures.

5h 11m • 1 change

4h 41m • 1 change

4h 46m • 1 change

4h 41m • 1 change

4h 56m • 1 change

5h 11m • 1 change

4h 41m • 1 change

4h 46m • 1 change

4h 56m • 1 change

5h 11m • 1 change

4h 41m • 1 change

4h 46m • 1 change

5h 11m • 1 change

4h 41m • 1 change

4h 46m • 1 change

4h 41m • 1 change
Want to know about travelling from Rome to Desio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Desio. However, there are services departing from Rome station and arriving at Desio station via Milano Rogoredo. The journey, including transfers, takes approximately 5h 13m.
Rome to Desio train services, operated by Trenitalia Frecce, depart from Roma Termini station.
Rome to Desio train services, operated by Trenitalia Frecce, arrive at Milano Rogoredo station.
Book your Rome to Desio train tickets online with Trenitalia Frecce and Trenord.
The distance between Rome and Desio is 490.8 km. The road distance is 582 km.
Trenitalia Frecce operates a train from Roma Termini to Milano Rogoredo hourly. Tickets cost €80–170 and the journey takes 3h 34m.