The average train between Rome and Domodossola takes 6h 9m and the fastest train takes 4h 57m. The train service runs several times per day from Rome to Domodossola. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Rome and Domodossola. The earliest departure is at 11:46 AM in the morning, and the last departure from Rome is at 8:11 PM which arrives into Domodossola at 8:43 AM. All services require a transfer, and take on average 6h 9m. The schedules shown below are for the next available departures.

4h 57m • 1 change
4h 58m • 1 change
4h 58m • 1 change
4h 57m • 1 change
4h 57m • 1 change
4h 58m • 1 change
4h 58m • 1 change
4h 57m • 1 change
4h 57m • 1 change
4h 58m • 1 change
4h 58m • 1 change
4h 57m • 1 changeWant to know about travelling from Rome to Domodossola? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Domodossola. However, there are services departing from Rome station and arriving at Domodossola station via Milano Centrale. The journey, including transfers, takes approximately 6h 9m.
Rome to Domodossola train services, operated by Trenitalia Frecce, depart from Roma Termini station.
Rome to Domodossola train services, operated by Trenitalia Frecce, arrive at Domodossola station.
Book your Rome to Domodossola train tickets online with Trenitalia Frecce and Trenitalia EuroCity.
The distance between Rome and Domodossola is 576.8 km. The road distance is 682 km.
You can take a train from Roma Termini to Domodossola via Milano Centrale in around 5h 41m.