The average train between Rome and Domodossola takes 7h 19m and the fastest train takes 5h 44m. The train service runs several times per day from Rome to Domodossola. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Rome and Domodossola. The earliest departure is at 7:30 AM in the morning, and the last departure from Rome is at 8:05 PM which arrives into Domodossola at 8:21 AM. All services require a transfer, and take on average 7h 19m. The schedules shown below are for the next available departures.

6h 34m • 1 change

5h 44m • 1 change

5h 44m • 1 change
Arrives next day

12h 16m • 1 change

6h 34m • 1 change

5h 44m • 1 change

5h 44m • 1 change
Arrives next day

12h 16m • 1 change

6h 34m • 1 change

5h 44m • 1 change

5h 44m • 1 change
Arrives next day

12h 16m • 1 change

6h 34m • 1 change

5h 44m • 1 change

5h 44m • 1 change
Arrives next day

12h 16m • 1 change
Want to know about travelling from Rome to Domodossola? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Domodossola. However, there are services departing from Rome station and arriving at Domodossola station via Milano Rogoredo. The journey, including transfers, takes approximately 7h 19m.
Rome to Domodossola train services, operated by ItaloTreno, depart from Roma Termini station.
Rome to Domodossola train services, operated by ItaloTreno, arrive at Domodossola station.
Book your Rome to Domodossola train tickets online with ItaloTreno and Trenitalia.
The distance between Rome and Domodossola is 576.8 km. The road distance is 681 km.
You can take a train from Roma Termini to Domodossola via Rho-Fiera Milano in around 5h 44m.