The average train between Rome and Istrana takes 7h 30m and the fastest train takes 5h 26m. The train service runs several times per day from Rome to Istrana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Rome and Istrana. The earliest departure is at 8:05 AM in the morning, and the last departure from Rome is at 7:00 PM which arrives into Istrana at 7:36 AM. All services require a transfer, and take on average 7h 30m. The schedules shown below are for the next available departures.

5h 31m • 1 change

5h 26m • 1 change
Arrives next day

12h 36m • 1 change

5h 31m • 1 change

5h 26m • 1 change
Arrives next day

12h 36m • 1 change

5h 31m • 1 change

5h 26m • 1 change
Arrives next day

12h 36m • 1 change
Want to know about travelling from Rome to Istrana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Istrana. However, there are services departing from Rome station and arriving at Istrana station via Padova. The journey, including transfers, takes approximately 7h 30m.
Rome to Istrana train services, operated by Trenitalia Frecce, depart from Roma Termini station.
Rome to Istrana train services, operated by Trenitalia Frecce, arrive at Istrana station.
Book your Rome to Istrana train tickets online with Trenitalia Frecce and Trenitalia.
The distance between Rome and Istrana is 421.2 km. The road distance is 518 km.
You can take a train from Roma Termini to Istrana via Padova in around 5h 6m.