The average train between Rome and Istrana takes 6h 26m and the fastest train takes 5h 1m. The train service runs several times per day from Rome to Istrana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Rome and Istrana. The earliest departure is at 8:20 AM in the morning, and the last departure from Rome is at 7:30 PM which arrives into Istrana at 7:36 AM. All services require a transfer, and take on average 6h 26m. The schedules shown below are for the next available departures.

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Want to know about travelling from Rome to Istrana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Istrana. However, there are services departing from Rome station and arriving at Istrana station via Padova. The journey, including transfers, takes approximately 6h 26m.
Rome to Istrana train services, operated by Trenitalia Frecce, depart from Roma Termini station.
Rome to Istrana train services, operated by Trenitalia Frecce, arrive at Istrana station.
Book your Rome to Istrana train tickets online with Trenitalia Frecce and Trenitalia.
The distance between Rome and Istrana is 421.2 km. The road distance is 518 km.
You can take a train from Roma Termini to Istrana via Padova in around 5h 19m.