The average train between Rome and Karlsruhe Hbf takes 12h 30m and the fastest train takes 10h 8m. The train service runs several times per day from Rome to Karlsruhe Hbf. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Rome and Karlsruhe Hbf. The earliest departure is at 6:25 AM in the morning, and the last departure from Rome is at 8:05 PM which arrives into Karlsruhe Hbf at 1:57 PM. All services require a transfer at Milano Centrale and take an average of 12h 30m. The schedules shown below are for the next available departures.


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13h 10m • 2 changesWant to know about travelling from Rome to Karlsruhe Hbf? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Karlsruhe Hbf. However, there are services departing from Rome station and arriving at Karlsruhe Hbf station via Milano Centrale. The journey, including transfers, takes approximately 12h 30m.
Rome to Karlsruhe Hbf train services, operated by ItaloTreno, depart from Roma Termini station.
Rome to Karlsruhe Hbf train services, operated by ItaloTreno, arrive at Karlsruhe Hauptbahnhof station.
Book your Rome to Karlsruhe Hbf train tickets online with ItaloTreno, Trenitalia EuroCity and Deutsche Bahn Intercity (DB IC).
The distance between Rome and Karlsruhe Hbf is 850.7 km. The road distance is 1,136 km.
You can take a train from Roma Termini to Karlsruhe Hauptbahnhof via Milano Centrale and Basel SBB in around 10h 37m.