The average train between Rome and Lake Iseo takes 7h 17m and the fastest train takes 5h 11m. The train service runs several times per day from Rome to Lake Iseo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Rome and Lake Iseo. The earliest departure is at 8:25 AM in the morning, and the last departure from Rome is at 7:25 PM which arrives into Lake Iseo at 7:36 AM. All services require a transfer, and take on average 7h 17m. The schedules shown below are for the next available departures.

5h 11m • 1 change

5h 11m • 1 change
Arrives next day

12h 11m • 1 change

5h 11m • 1 change

5h 11m • 1 change
Arrives next day

12h 11m • 1 change

5h 11m • 1 change

5h 11m • 1 change
Arrives next day

12h 11m • 1 change

5h 11m • 1 change

5h 11m • 1 change
Arrives next day

12h 11m • 1 change
Want to know about travelling from Rome to Lake Iseo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Lake Iseo. However, there are services departing from Rome station and arriving at Lake Iseo station via Brescia. The journey, including transfers, takes approximately 7h 17m.
Rome to Lake Iseo train services, operated by ItaloTreno, depart from Roma Termini station.
Rome to Lake Iseo train services, operated by ItaloTreno, arrive at Brescia station.
Book your Rome to Lake Iseo train tickets online with ItaloTreno and Trenord.
The distance between Rome and Lake Iseo is 467 km. The road distance is 675 km.
ItaloTreno operates a train from Roma Termini to Brescia every 4 hours. Tickets cost €80–160 and the journey takes 4h 6m.