The average train between Rome and Lissone takes 5h 9m and the fastest train takes 4h 2m. The train service runs several times per day from Rome to Lissone. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Rome and Lissone. The earliest departure is at 4:55 AM at night, and the last departure from Rome is at 7:50 PM which arrives into Lissone at 7:17 AM. All services require a transfer, and take on average 5h 9m. The schedules shown below are for the next available departures.

4h 52m • 1 change

5h 7m • 1 change

4h 37m • 1 change

4h 42m • 1 change

4h 52m • 1 change

5h 7m • 1 change

4h 37m • 1 change

4h 42m • 1 change

5h 7m • 1 change

4h 37m • 1 change

4h 42m • 1 change

4h 37m • 1 change

4h 52m • 1 change

4h 27m • 1 change

4h 32m • 1 change

4h 27m • 1 change
Want to know about travelling from Rome to Lissone? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Lissone. However, there are services departing from Rome station and arriving at Lissone station via Milano Rogoredo. The journey, including transfers, takes approximately 5h 9m.
Rome to Lissone train services, operated by Trenitalia Frecce, depart from Roma Termini station.
Rome to Lissone train services, operated by Trenitalia Frecce, arrive at Milano Rogoredo station.
Book your Rome to Lissone train tickets online with Trenitalia Frecce and Trenord.
The distance between Rome and Lissone is 488.6 km. The road distance is 580 km.
Trenitalia Frecce operates a train from Roma Termini to Milano Rogoredo hourly. Tickets cost €80–170 and the journey takes 3h 34m.