The average train between Rome and Piazza del Duomo takes 3h 41m and the fastest train takes 3h 15m. There is a train service every few hours from Rome to Piazza del Duomo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Rome and Piazza del Duomo. The earliest departure is at 5:10 AM in the morning, and the last departure from Rome is at 8:10 PM which arrives into Piazza del Duomo at 11:55 PM. All services require a transfer at Milano Rogoredo and take an average of 3h 41m. The schedules shown below are for the next available departures.

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3h 46m • 1 changeWant to know about travelling from Rome to Piazza del Duomo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Piazza del Duomo. However, there are services departing from Roma Termini station and arriving at Milano Rogoredo station via Milano Rogoredo station. The journey, including transfers, takes approximately 3h 41m.
Rome to Piazza del Duomo train services, operated by Trenitalia Frecce, depart from Roma Termini station.
Rome to Piazza del Duomo train services, operated by Trenitalia Frecce, arrive at Milano Rogoredo station.
The distance between Rome and Piazza del Duomo is 477.2 km. The road distance is 571 km.
Trenitalia Frecce operates a train from Roma Termini to Milano Rogoredo every 30 minutes. Tickets cost €75–130 and the journey takes 3h 1m. ItaloTreno also services this route 3 times a day.