Rome to San Sepolcro Trains

Trip Overview

The average train between Rome and San Sepolcro takes 3h 37m and the fastest train takes 3h 8m. There is a train service every few hours from Rome to San Sepolcro. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 37m
Duration: 440 km
Distance: €73
Average price: Hourly
Frequency

Train

best

Take the train from Roma Termini to Bologna centraletrain 9968 / ...
Take the train from Bologna Centrale to Parmatrain Fr

3h 34m

€54–157

Rome to San Sepolcro train times

Trains run hourly between Rome and San Sepolcro. The earliest departure is at 5:40 AM in the morning, and the last departure from Rome is at 7:25 PM which arrives into San Sepolcro at 11:20 PM. All services require a transfer at Bologna Centrale and take an average of 3h 37m. The schedules shown below are for the next available departures.

Departing Wednesday, August 26, 2026

7:25 PM → 11:20 PM
3h 55m • 1 change

Departing Thursday, August 27, 2026

5:40 AM → 9:13 AM
3h 33m • 1 change
5:55 AM → 9:31 AM
3h 36m • 1 change
6:30 AM → 10:07 AM
3h 37m • 1 change
7:05 AM → 10:13 AM
3h 8m • 1 change
Show more

Departing Friday, August 28, 2026

5:40 AM → 9:13 AM
3h 33m • 1 change
5:55 AM → 9:31 AM
3h 36m • 1 change
6:30 AM → 10:07 AM
3h 37m • 1 change
7:05 AM → 10:13 AM
3h 8m • 1 change
Show more

Departing Saturday, August 29, 2026

5:40 AM → 9:13 AM
3h 33m • 1 change
5:55 AM → 9:31 AM
3h 36m • 1 change
6:30 AM → 10:07 AM
3h 37m • 1 change
7:05 AM → 10:13 AM
3h 8m • 1 change
Show more

Departing Sunday, August 30, 2026

5:40 AM → 9:13 AM
3h 33m • 1 change
5:55 AM → 9:31 AM
3h 36m • 1 change
6:30 AM → 10:07 AM
3h 37m • 1 change
7:05 AM → 10:13 AM
3h 8m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Rome to San Sepolcro? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.