The average train between Rome and Seregno takes 4h 11m and the fastest train takes 3h 41m. There is a train service every few hours from Rome to Seregno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Rome and Seregno. The earliest departure is at 5:05 AM in the morning, and the last departure from Rome is at 8:11 PM which arrives into Seregno at 6:01 AM. All services require a transfer, and take on average 4h 11m. The schedules shown below are for the next available departures.

3h 41m • 1 change
3h 46m • 1 change
3h 41m • 1 change
3h 45m • 1 change
4h 56m • 1 change
3h 46m • 1 change
3h 46m • 1 change
3h 41m • 1 change
4h 56m • 1 change
3h 46m • 1 change
4h 16m • 1 change
3h 41m • 1 change
3h 41m • 1 change
3h 46m • 1 change
3h 46m • 1 change
3h 41m • 1 changeWant to know about travelling from Rome to Seregno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Seregno. However, there are services departing from Rome station and arriving at Seregno station via Milano Centrale. The journey, including transfers, takes approximately 4h 11m.
Rome to Seregno train services, operated by Trenitalia Frecce, depart from Roma Termini station.
Rome to Seregno train services, operated by Trenitalia Frecce, arrive at Milano Centrale station.
Book your Rome to Seregno train tickets online with Trenitalia Frecce and Swiss Federal Railways (SBB CFF FFS).
The distance between Rome and Seregno is 493.6 km. The road distance is 587 km.
Trenitalia Frecce operates a train from Roma Termini to Milano Centrale every 30 minutes. Tickets cost €75–140 and the journey takes 3h 39m. ItaloTreno also services this route 4 times a day.