The average train between Rome and Seregno takes 4h 21m and the fastest train takes 3h 51m. There is a train service every few hours from Rome to Seregno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Rome and Seregno. The earliest departure is at 5:40 AM in the morning, and the last departure from Rome is at 8:05 PM which arrives into Seregno at 6:01 AM. All services require a transfer, and take on average 4h 21m. The schedules shown below are for the next available departures.

4h 21m • 1 change

3h 56m • 1 change

4h 11m • 1 change

3h 56m • 1 change

4h 21m • 1 change

3h 56m • 1 change

4h 11m • 1 change

3h 56m • 1 change

4h 21m • 1 change

3h 56m • 1 change

4h 11m • 1 change

3h 56m • 1 change

4h 21m • 1 change

3h 56m • 1 change

4h 11m • 1 change

3h 56m • 1 change
Want to know about travelling from Rome to Seregno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Seregno. However, there are services departing from Rome station and arriving at Seregno station via Milano Centrale. The journey, including transfers, takes approximately 4h 21m.
Rome to Seregno train services, operated by ItaloTreno, depart from Roma Termini station.
Rome to Seregno train services, operated by ItaloTreno, arrive at Milano Centrale station.
Book your Rome to Seregno train tickets online with ItaloTreno and Swiss Federal Railways (SBB CFF FFS).
The distance between Rome and Seregno is 493.6 km. The road distance is 602 km.
ItaloTreno operates a train from Roma Termini to Milano Centrale every 30 minutes. Tickets cost €75–150 and the journey takes 3h 5m.