The average train between Rome and Sesto Calende takes 5h 31m and the fastest train takes 4h 22m. The train service runs several times per day from Rome to Sesto Calende. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Rome and Sesto Calende. The earliest departure is at 7:30 AM in the morning, and the last departure from Rome is at 8:05 PM which arrives into Sesto Calende at 7:04 AM. All services require a transfer, and take on average 5h 31m. The schedules shown below are for the next available departures.

5h 2m • 1 change

4h 49m • 1 change

4h 22m • 1 change

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4h 22m • 1 change

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4h 22m • 1 change

4h 22m • 1 change

5h 2m • 1 change

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4h 22m • 1 change
Want to know about travelling from Rome to Sesto Calende? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Sesto Calende. However, there are services departing from Rome station and arriving at Sesto Calende station via Milano Rogoredo. The journey, including transfers, takes approximately 5h 31m.
Rome to Sesto Calende train services, operated by ItaloTreno, depart from Roma Termini station.
Rome to Sesto Calende train services, operated by ItaloTreno, arrive at Sesto Calende station.
Book your Rome to Sesto Calende train tickets online with ItaloTreno and Trenitalia.
The distance between Rome and Sesto Calende is 526.1 km. The road distance is 617 km.
You can take a train from Roma Termini to Sesto Calende via Rho-Fiera Milano in around 4h 24m.