The average train between Saint-Louis and Lyon takes 7h 31m and the fastest train takes 3h 33m. The train service runs several times per day from Saint-Louis to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Saint-Louis and Lyon. The earliest departure is at 10:30 AM in the morning, and the last departure from Saint-Louis is at 7:30 PM which arrives into Lyon at 10:59 AM. All services require a transfer, and take on average 7h 31m. The schedules shown below are for the next available departures.

4h 35m • 1 change

3h 33m • 1 change

4h 28m • 1 change
Arrives next day

15h 29m • 1 change

5h 5m • 1 change

5h 4m • 1 change
Arrives next day

15h 35m • 1 change

5h 5m • 1 change

5h 4m • 1 change
Arrives next day

15h 35m • 1 change
Want to know about travelling from Saint-Louis to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Saint-Louis to Lyon. However, there are services departing from Saint-Louis station and arriving at Lyon station via Lyon Part Dieu. The journey, including transfers, takes approximately 7h 31m.
Saint-Louis to Lyon train services, operated by Société Nationale des Chemins de fer Français (SNCF), depart from Mulhouse Ville station.
Saint-Louis to Lyon train services, operated by Société Nationale des Chemins de fer Français (SNCF), arrive at Lyon Part Dieu station.
Book your Saint-Louis to Lyon train tickets online with Société Nationale des Chemins de fer Français (SNCF) and TGV inOui.
The distance between Saint-Louis and Lyon is 291.3 km. The road distance is 423 km.
TGV inOui operates a train from Mulhouse Ville to Lyon Part Dieu every 3 hours. Tickets cost €80–130 and the journey takes 3h 7m.