The average train between Salerno and Isernia takes 3h 44m and the fastest train takes 2h 26m. The train service runs several times per day from Salerno to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Salerno and Isernia. The earliest departure is at 4:52 AM at night, and the last departure from Salerno is at 7:17 PM which arrives into Isernia at 9:43 PM. All services require a transfer, and take on average 3h 44m. The schedules shown below are for the next available departures.

4h 29m • 1 change

6h 9m • 1 change

3h 36m • 1 change

2h 37m • 1 change

4h 29m • 1 change

6h 9m • 1 change

3h 36m • 1 change

2h 37m • 1 change

4h 29m • 1 change

6h 9m • 1 change

2h 36m • 1 change

4h 3m • 1 change

4h 29m • 1 change

6h 9m • 1 change

2h 36m • 1 change

2h 37m • 1 change

4h 29m • 1 change

6h 9m • 1 change

2h 36m • 1 change

2h 37m • 1 change

4h 29m • 1 change

6h 9m • 1 change

2h 36m • 1 change

2h 37m • 1 change
Want to know about travelling from Salerno to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Salerno to Isernia. However, there are services departing from Salerno station and arriving at Isernia station via Caserta. The journey, including transfers, takes approximately 3h 44m.
Salerno to Isernia train services, operated by Trenitalia, depart from Salerno station.
Salerno to Isernia train services, operated by Trenitalia, arrive at Isernia station.
Book your Salerno to Isernia train tickets online with Trenitalia.
The distance between Salerno and Isernia is 112.6 km. The road distance is 153 km.
You can take a train from Salerno to Isernia via Caserta in around 3h 20m.