The average train between Santa Ana and La Mesa takes 2h 48m and the fastest train takes 2h 33m. There is a train service every few hours from Santa Ana to La Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Santa Ana and La Mesa. The earliest departure is at 7:01 AM in the morning, and the last departure from Santa Ana is at 11:01 PM which arrives into La Mesa at 5:04 AM. All services require a transfer at San Diego Old Town Transportation Center and take an average of 2h 48m. The schedules shown below are for the next available departures.

2h 33m • 1 change

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2h 33m • 1 change
Want to know about travelling from Santa Ana to La Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Santa Ana to La Mesa. However, there are services departing from Santa Ana station and arriving at La Mesa station via San Diego Old Town Transportation Center. The journey, including transfers, takes approximately 2h 48m.
Santa Ana to La Mesa train services, operated by Amtrak, depart from Santa Ana station.
Santa Ana to La Mesa train services, operated by Amtrak, arrive at San Diego Old Town Transportation Center station.
The distance between Santa Ana and La Mesa is 134.1 km. The road distance is 160 km.
Amtrak operates a train from Santa Ana to San Diego Old Town Transportation Center hourly. Tickets cost $28–60 and the journey takes 1h 51m.