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Santa Ana to St. Louis trains

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Trip Overview

The average train between Santa Ana and St. Louis takes 43h 50m and the fastest train takes 42h 54m. The train runs, on average, 5 times per week from Santa Ana to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

43h 50m
Duration
2,056 mi
Distance
$1,288
Average price
5 times a week
Frequency

Santa Ana to St. Louis train times

Trains run 5 times a week between Santa Ana and St. Louis. The earliest departure is at 4:04 PM in the afternoon, and the last departure from Santa Ana is at 5:26 PM which arrives into St. Louis at 2:20 PM. All services require a transfer at Fullerton Amtrak Station and take an average of 43h 50m. The schedules shown below are for the next available departures.

Departing Friday, October 30, 2026

  •  → 

    Arrives +2 days

    Metrolink TrainsAmtrakAmtrak43h 54m • 2 changes

Departing Saturday, October 31, 2026

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    Arrives +2 days

    AmtrakAmtrakAmtrak45h 16m • 2 changes

Departing Sunday, November 1, 2026

  •  → 

    Arrives +2 days

    AmtrakAmtrakAmtrak44h 16m • 2 changes

Departing Monday, November 2, 2026

  •  → 

    Arrives +2 days

    Metrolink TrainsAmtrakAmtrak42h 54m • 2 changes

Departing Tuesday, November 3, 2026

  •  → 

    Arrives +2 days

    Metrolink TrainsAmtrakAmtrak42h 54m • 2 changes

Frequently asked questions

Want to know about travelling from Santa Ana to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santa Ana to St. Louis.ExpandLaunch map view
  • Distance: 2,056.4 mi
  • Duration: 43h 50m

What companies run services between Santa Ana, CA, USA and St. Louis, MO, USA?

You can take a train from Santa Ana to St. Louis via Fullerton Amtrak Station and Kansas City in around 42h 27m.

Operators