The average train between Santa Fe Depot and Irvine takes 2h 55m and the fastest train takes 2h 19m. The train service runs several times per day from Santa Fe Depot to Irvine. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Santa Fe Depot and Irvine. The earliest departure is at 4:01 AM at night, and the last departure from Santa Fe Depot is at 9:01 PM which arrives into Irvine at 5:20 AM. All services require a transfer, and take on average 2h 55m. The schedules shown below are for the next available departures.

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 19m • 1 change

2h 27m • 1 change

2h 28m • 1 change

2h 29m • 1 change

2h 34m • 1 change
Want to know about travelling from Santa Fe Depot to Irvine? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Santa Fe Depot to Irvine. However, there are services departing from Santa Fe Depot station and arriving at Irvine station via Irvine. The journey, including transfers, takes approximately 2h 55m.
Santa Fe Depot to Irvine train services, operated by Amtrak, depart from San Diego station.
Santa Fe Depot to Irvine train services, operated by Amtrak, arrive at Irvine station.
The distance between Santa Fe Depot and Irvine is 122.1 km. The road distance is 141 km.
Amtrak operates a train from San Diego to Irvine hourly. Tickets cost $27–55 and the journey takes 1h 50m.