The average train between Santa Margherita and Rome takes 4h 49m and the fastest train takes 4h 2m. The train service runs several times per day from Santa Margherita to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Santa Margherita and Rome. The earliest departure is at 6:23 AM in the morning, and the last departure from Santa Margherita is at 7:23 PM which arrives into Rome at 9:19 AM. All services require a transfer at Milano Greco Pirelli and take an average of 4h 49m. The schedules shown below are for the next available departures.

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4h 2m • 1 changeWant to know about travelling from Santa Margherita to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Santa Margherita to Rome. However, there are services departing from Milano Centrale station and arriving at Roma Termini station via Roma Termini station. The journey, including transfers, takes approximately 4h 49m.
Santa Margherita to Rome train services, operated by ItaloTreno, depart from Milano Centrale station.
Santa Margherita to Rome train services, operated by ItaloTreno, arrive at Roma Termini station.
The distance between Santa Margherita and Rome is 490.9 km. The road distance is 589 km.
ItaloTreno operates a train from Milano Centrale to Roma Termini every 30 minutes. Tickets cost €65–110 and the journey takes 3h 5m.