The average train between Santa Margherita and Siena takes 5h 3m and the fastest train takes 4h 47m. The train service runs several times per day from Santa Margherita to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Santa Margherita and Siena. The earliest departure is at 8:53 AM in the morning, and the last departure from Santa Margherita is at 5:53 PM which arrives into Siena at 11:16 PM. All services require a transfer at Milano P.Garibaldi and take an average of 5h 3m. The schedules shown below are for the next available departures.


4h 47m • 2 changes


5h 15m • 2 changes


4h 47m • 2 changes


5h 23m • 2 changes


4h 47m • 2 changes


5h 15m • 2 changes


4h 47m • 2 changes


5h 23m • 2 changes
Want to know about travelling from Santa Margherita to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Santa Margherita to Siena. However, there are services departing from Santa Margherita station and arriving at Siena station via Firenze S.M.N.. The journey, including transfers, takes approximately 5h 3m.
Santa Margherita to Siena train services, operated by Trenord, depart from Milano P.Garibaldi station.
Santa Margherita to Siena train services, operated by Trenord, arrive at Siena station.
The distance between Santa Margherita and Siena is 306.5 km. The road distance is 417 km.
You can take a train from Desio to Siena via Milano P.Garibaldi and Firenze S.M.N. in around 5h 25m.